PrizePicks NFL Player Props For Week 4: Go High On Amon-Ra St. Brown

The first month of the NFL season was exciting, with many close games. The league's parity has led to some unexpected teams emerging as contenders, while others have started slowly.

When you're following games on a Sunday, it’s exciting to set up a PrizePicks lineup, track the league's top players and cash out big.

Here are three players that should be in your PrizePicks lineup in Week 4.

Week 4 PrizePicks for NFL Props

Amon-Ra St. Brown More Than 75.5 Receiving Yards

The Lions have consistently ranked among the league’s top offenses, and 2026 is no exception. This season, they rank third in points per game (31.0) and touchdowns per game (4.0).

It’s easy to be a top unit when you have star players at key positions. Running back Jahmyr Gibbs is having another excellent season, ranking third in rushing yards (304) and second in rushing touchdowns (4).

Detroit also has one of the game’s top wide receivers, with Amon-Ra St. Brown serving as the passing-game catalyst. He doesn’t have many receiving yards, ranking only 14th (228), but he’s second in receiving touchdowns (5). That’s because Jared Goff trusts St. Brown in the red zone, with 9 targets inside the 20, the most in the NFL.

The Lions’ biggest problem, and the one that could hurt their Super Bowl chances, is their abysmal defense. Detroit is allowing the most points per game (31.7).

The Lions have played two one-possession games this season, so with the game constantly close, they’ll likely pass throughout the matchup.

The Panthers' secondary is depleted heading into this game, with starting cornerbacks Jaycee Horn and Mike Jackson placed on IR. That could be dangerous with backups covering one of the league's best receivers.

Trey McBride More than 7.5 Receptions

Some things are staples on an autumn Sunday: the wings are hot, the drinks are cold and Trey McBride gets a ton of targets.

McBride enters this week leading the team in target share (30.3%) and has caught at least 8 passes in every game. He’s one of the most utilized tight ends in the passing game, leading the position in routes run (120) and first-read targets (27).

The Giants present a great matchup for tight ends. They’ve allowed 18 receptions to tight ends, the sixt most in the NFL, and 29 targets, the eighth most, suggesting below-average coverage of tight ends.

Matthew Stafford More Than 252.5 Passing Yards

Matthew Stafford and the Rams drew concern after a disastrous showing against the 49ers in Australia. Los Angeles might have put to rest any questions about regression the following week against the Giants, then came back late against the Broncos before falling short of the win.

Over the past two weeks, Stafford has been the NFL’s best quarterback, leading the league in passing yards (717) and touchdowns (6). It isn’t just his receivers doing the legwork; Stafford is sixth in average depth of target (10.2), and his 10.5 air yards per attempt rank second this season.

Philadelphia's basic defensive stats don’t favor Stafford, but a deeper look shows this is a great matchup for the Rams QB. The Eagles rank ninth in passing yards per game (193.0), but they’ve played the Commanders and Titans, both of which rank in the bottom 6 in passing yards per game. Last week against the Bears, the Eagles’ defense might have been exposed, as they allowed Case Keenum, who hadn’t started an NFL game since 2023, to throw for 247 yards and 2 touchdowns.

Some metrics don’t favor Philly’s defense: they rank 23rd in EPA allowed per dropback (+0.17) and 15th in dropback success rate (45.6%).

Puka Nacua will return for this game after missing the past two with a groin injury. Even if he isn’t 100% and is used as a decoy, the team still has Davante Adams, who has 332 receiving yards over his last two games.